Spravato® is nasal esketamine, a more specific form of ketamine designed to treat depression. Spravato® takes the effective part of ketamine and isolates that and then gets rid of the sedating part of ketamine that is not believed to be as important for depression.

Spravato® nasal spray is FDA-approved for people with depression who have not experienced adequate improvement with antidepressant medications.

A typical round of esketamine nasal spray treatment is broken up into three phases: Phase 1: 2 treatments a week for 4 weeks Phase 2: 1 treatment a week for 4 weeks Phase 3: 1 treatment every 1-2 weeks Before coming to each appointment, be sure you avoid eating anything for two hours. You should also avoid large amounts of fluid for 30 minutes before an appointment. Each session takes place at Depression Healing Clinic. Once you arrive, you'll sit in a chair and self-administer the nasal spray. Your blood pressure is checked at the start of the session, 40 minutes into treatment, and prior to leaving the clinic. You must stay at the clinic for no less than 2 hours. Make sure you have someone to drive you home.

You will either do 2 or 3 sprays in your nostril depending on your prescription.

Yes, you have to be on an antidepressant medication to receive nasal esketamine spray.

No. Nasal esketamine must be given at a REMS (risk evaluation and mitigation system) certified clinic.

No. Spravato® is FDA-approved for people with treatment resistant depression who have not experienced adequate improvement with antidepressant medications.

You should not take Spravato® if you have: Uncontrolled hypertension History of strokes or brain bleeds Abnormal blood vessels at risk of bleeding, such as aneurysms or ateriorvenous malformations (AVMs) Sensitivity to esketimine

Yes. Spravato is covered by many major insurance companies.